2008 Mercedes-Benz E320 Bluetec
Big honkin’ luxury sedans aren’t usually associated with fuel economy, especially one as nicely outfitted and expensive as the $53,025 Mercedes-Benz E320 Bluetec. However, that “Bluetec” badge means “diesel,” and that means excellent fuel economy: 23 in the city, 32 on the highway and a combined of 26. For those of you keeping score, the combined is two mpg better than the Lexus RX 400h listed earlier, and its highway mpg is the best of all the cars on this list. Throw in the fact that it’s got gobs of torque and plenty of power and you have virtually sin-free luxury.